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DeCS
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Descriptor English:
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Neuroleptic Malignant Syndrome
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Descriptor Spanish:
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Síndrome Neuroléptico Maligno
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Descriptor Portuguese:
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Síndrome Maligna Neuroléptica
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Synonyms English:
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Neuroleptic-Induced Neuroleptic Malignant Syndrome
Neuroleptic-Malignant Syndrome, Neuroleptic Induced
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Tree Number:
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C10.228.140.079.737
C10.720.737
C25.723.705.600
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Definition English:
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A potentially fatal syndrome associated primarily with the use of neuroleptic agents (see ANTIPSYCHOTIC AGENTS) which are in turn associated with dopaminergic receptor blockade (see RECEPTORS, DOPAMINE) in the BASAL GANGLIA and HYPOTHALAMUS, and sympathetic dysregulation. Clinical features include diffuse MUSCLE RIGIDITY; TREMOR; high FEVER; diaphoresis; labile blood pressure; cognitive dysfunction; and autonomic disturbances. Serum CPK level elevation and a leukocytosis may also be present. (From Adams et al., Principles of Neurology, 6th ed, p1199; Psychiatr Serv 1998 Sep;49(9):1163-72) |
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Indexing Annotation English:
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caused by tranquilizing agents so do not use /chem ind
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History Note English:
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1986(1985)
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Allowable Qualifiers English:
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Record Number:
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9650
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Unique Identifier:
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D009459
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Occurrence in VHL:
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Similar:
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DeCS CID-10 SciELO LILACS LIS
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